Prof. Claude A. Farrugia
B.Pharm.(Hons.)(Melit.), Ph.D.(UIC), FIScT, FRSC, MAPS, MRSB, MTOPRA, SRPharmS

Publications and Presentations

Original Papers

• Mazzonello, A., Valdramidis, V., Farrugia, C., Grima, J.N., and Gatt, R.: Synthesis and characterization of silver nanoparticles. Journal of Modern Engineering Research 7: 41, 2017
• Millan-Sango, D., Garroni, E., Farrugia, C., Van Impe, J.F.M., and Valdramidis, V.P.: Determination of the efficacy of ultrasound combined with essential oils on the decontamination of Salmonella inoculated lettuce leaves. LWT - Food Science and Technology 73: 80, 2016
• Duca, D., and Farrugia, C.: Development and validation of HPLC-PDA assay of Frangula emodin. Mediterranean Journal of Chemistry 5: 374, 2016
• Sciberras, J., Galloway, S., Fenech, A., Farrugia, C., Duca, D., Grech, G., and Mifsud, J.: The effect of turmeric (curcumin) supplementation on cytokine and inflammatory marker responses following 2 hours of endurance cycling. Journal of the International Society of Sports Nutrition 12: 5, 2015
• Mazzitelli, O., Calleja, A., Sardella, D., Farrugia, C., and Zammit-Mangion, M.: Analysis of the molecular diversity of Olea europaea in the Mediterranean island of Malta. Genetic Resources and Crop Evolution 2014
• Vella, M., Hunter, T., Farrugia, C., Pearson, A.R., and Hunter, G.: Purification and characterisation of xanthine oxidoreductases from local bovids in Malta. Advances in Enzyme Research 2: 54-63, 2014
• Popova, M., Trusheva, B., Cutajar, S., Antonova, D., Mifsud, D., Farrugia, C., and Bankova, V.: Identification of the plant origin of the botanical biomarkers of Mediterranean type propolis. Natural Product Communications 7: 569-570, 2012
• Popova, M., Trusheva, B., Antonova, D., Cutajar, S., Mifsud, D., Farrugia, C., Tsvetkova, I., Najdenski, H., and Bankova, V.: The specific chemical profile of Mediterranean propolis from Malta. Food Chemistry 126: 1431-1435, 2011
• Farrugia, C.A., Mifsud, J., and Sinagra, E.: Gelatin nanoparticle production: an in-process study using size exclusion chromatography. Xjenza 10: 43-46, 2005
• Farrugia, C.A., and Groves, M.J.: The Activity of Unloaded Gelatin Nanoparticles on Murine B16-F0 Melanoma Growth In Vivo. Anticancer Res. 19: 1027-1032, 1999
• Farrugia, C.A., and Groves, M.J.: Gelatin Behaviour in Dilute Aqueous Solution: Designing a Nanoparticulate Formulation. J. Pharm. Pharmacol. 51: 643-649, 1999
• Farrugia, C.A., Farrugia I.V., and Groves, M.J.: Comparison of the Molecular Weight Distribution of Gelatin Fractions by Size-Exclusion Chromatography and Light Scattering. Pharm. Pharmacol. Commun. 4: 1-5, 1998
• Farrugia, C.A., Zarb Adami, M., Gatt, M., and Serracino Inglott, A.: Impact of a Computerized Medication Record System on Length of Hospitalisation. Int. Pharm. J. 6: 69-71, 1992

Review Articles and Editorials

• Farrugia, C.: Newton’s laws, Einstein’s theory or just plain science? european Industrial Pharmacy 33: 3, 2017
• Farrugia, C.: To speed or two speed: is that the question? european Industrial Pharmacy 32: 3, 2017
• Farrugia, C.: You are not alone european Industrial Pharmacy 31: 3, 2016
• Farrugia, C.: The price is right? european Industrial Pharmacy 30: 3, 2016
• Farrugia, C.: The journey and the goal european Industrial Pharmacy 26: 3, 2015
• Paccioni, J.P., and Farrugia, C.: A patient in every box european Industrial Pharmacy 25: 3, 2015
• Farrugia, C.: Will they? Won't they? european Industrial Pharmacy 23: 3, 2014
• Farrugia, C.: The shape of pharma to come. european Industrial Pharmacy 22: 3, 2014
• Farrugia, C.: EIPG elects a new President: Martini passes the baton to Paccioni. european Industrial Pharmacy 17: 3, 2013
• Farrugia, C.A., and Savvas, K.: Pricing of medicinal products: considerations in a small market state. Journal of the Malta College of Pharmacy Practice 15: 30-34, 2009
• Cilia Pisani, R., Vella Brincat, G., and Farrugia, C.: The roles and responsibilities of the Qualified Person in the pharmaceutical industry. Journal of the Malta College of Pharmacy Practice 15: 44-45, 2009
• Farrugia, C.A.: The Pharmaceutical Manufacturing Industry: A look to the future. Industry Today 56: 40-41, 2005
• Farrugia, C.A.: Controlled temperature storage of medicinals: good practice measures in the community pharmacy. The Chronic*ill 10: 30-33, 2005
• Farrugia, C.A.: Flow-Through Dissolution Testing: A Comparison with Stirred-Beaker Methods. The Chronic*ill 6: 27-29, 2002
• Farrugia, C.A.: Quality in Pharmaceutical Manufacturing: a Review of European Union Legislation. EPSA Newsletter 8: 21-22, 2000
• Farrugia, C.A.: The Formulation of Biotechnology Products. EPSA Newsletter 7: 18-19, 1999
• Farrugia, C.A.: The Antiplatelet Activity of Aspirin. The Chronic*ill 3: 21-25, 1999

Conference Proceedings

• Pace, F., Lia, F., and Farrugia, C.: Physicochemical Properties of Medicinal Compounds in the World Health Organisation’s Anatomical Therapeutic Chemical Classification. (57° Simposio AFI, Rimini, 2016)
• Cauchi, G., and Farrugia, C.: Development of a Single Optimized Method for the HPLC Analysis of Angiotensin II Receptor Blocker (ARB) Antagonists. (56° Simposio AFI, Rimini, 2016)
• Pace, F., Lia, F., and Farrugia, C.: Assessment of Solubility as a Physicochemical Classifying Parameter in the Anatomical Therapeutic Classification. (56° Simposio AFI, Rimini, 2016)
• Mallia, L., Sinagra, E., and Farrugia, C.: Influence of pH and Gelatin Concentration on the Size and Zeta Potential of Gelatin Colloidal Dispersions. (Tenth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, 2016)
• Lia, F., Farrugia, C., and Zammit Mangion, M.: Determination of Antioxidant Activity of Olive Oil Phenolic Extracts. (9th World Congress on Polyphenols Applications, St Julian's, 2015)
• Fenech, M., and Farrugia, C.: A Correlation of Physicochemical Properties of Selected Medicinal Compounds to their Anatomical Therapeutic Chemical Classification. (PharmSci 2014, Hatfield, 2014)
• Borg, D.A., and Farrugia, C.: Chromatographic and Degradation Studies of Frangula Emodin. (Ninth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, 2014)
• Ellul, M., Sinagra, E., and Farrugia, C.: Quality by Design Optimization of Active Pharmaceutical Ingredient Dispersions Based on Physicochemical Parameters. (Ninth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, 2014)
• Aquilina, A., Aquilina, S., Cortis, R., Farrugia, C., and Sinagra, E.: Physicochemical Aspects of the Higher Order Structure of Gelatin in Dilute Aqueous Solution. (10th International Conference of Lithuanian Chemists, 2011)
• Ellul, M., Schembri, O., and Farrugia, C.: Optimisation of Sample Preparation in the Particle-Size Characterization of Active Pharmaceutical Ingredients by Laser Diffraction. (51° Simposio AFI, Rimini, 2011)
• Abela, D., Schembri, O., and Farrugia, C.: A Chromatographic Determination of the Stability of Solutions of Amlodipine Benazepril and Amlodipine Besilate. (Seventh World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Malta, 2010)
• Cutajar, S., Farrugia, C., Mifsud, D., Popova, M., Antonova, D., and Bankova, V.: Chemical Characterisation of Maltese Propolis in Relation to Botanical Sources. (Seventh World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Malta, 2010)
• Farrugia, C., Schembri, M., and Sinagra, E.: The Influence of pH, Temperature and Salt on the Ethanolic Desolvation of Dilute Cold Water Fish Skin Gelatin from Aqueous Solution. (Seventh World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Malta, 2010)
• Borg, D., Frey, H.H., and Farrugia, C.: A Study for the Method Transfer of Acetylsalicylic Acid from HPLC to RRLC. (Seventh World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Malta, 2010)
• Fenech, A., Schiro, J., Farrugia, C., and Baluci, C.: A Comparative Study of the Effect of Cleaning Treatments on Two Historic Papers: A Preliminary Study. Proceedings of the 2nd Residential Summer School on Chemistry and Conservation Science Palermo (Italy), 2008
• Knupfer, S., Sinagra, E., and Farrugia, C.A.: Surfactant Effects on the Ethanolic Desolvation of Dilute Gelatin Solutions. (Sixth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, 2008)
• Cassar, R., Farrugia, C.A., and Sinagra, E.: Temperature Effects on the Ethanolic Desolvation of Dilute Gelatin-Sodium Dodecyl Sulfate Solutions. (Sixth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, 2008)
• Cortis, R., Farrugia, C.A., and Sinagra, E.: The Influence of pH, Temperature and Salt on the Ethanolic Desolvation of Dilute Gelatin Solutions. (Sixth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, 2008)
• Storm, J., Farrugia, C.A., and Sinagra, E.: The Effect of Sodium Dodecyl Sulfate on the Ethanolic Fractionation of Dilute Gelatin Solutions. (Fifth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva, 2006)
• Storm, J., Farrugia, C.A., and Sinagra, E.: The Effect of Sodium Chloride on the pH-dependant Ethanolic Fractionation of Gelatin-SDS Mixtures. (Fifth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva, 2006)
• Blei, C., Farrugia, C.A., Mifsud, J., and Sinagra, E.: Potentiometric Studies on Gelatin Solutions and Gelatin Nanoparticle Dispersions. (International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 2004)
• Aquilina, A., Müller, D., Farrugia, C.A., and Sinagra, E.: The Effect of Sodium Chloride on Type-Based Differences in Gelatin Desolvation Behaviour. (International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 2004)
• Aquilina, A., Farrugia, C.A., and Sinagra, E.: The Effect of Sodium Chloride on Ethanolic Fractionation of Dilute Gelatin Solutions. (Fourth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Firenze, 2002)
• Farrugia, C.A., and Groves, M.J.: Inhibition of In Vivo Murine Melanoma Growth Using Gelatin Nanoparticles. Cancer Detection and Prevention 24: S-257, 2000 (Fifth International Symposium on Predictive Oncology and Therapy, Geneva, 2000)
• Farrugia, C.A., and Groves, M.J.: Deconvolution of Complex Chromatograms: A Case Study of Gelatin. (Third World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Berlin, 2000)
• Farrugia, C.A., and Groves, M.J.: Effect of Molecular Weight Profile on Gelatin Nanoparticulate Formation. PharmSci 1: S-195, 1998 (American Association of Pharmaceutical Scientists Annual Meeting and Exposition, San Francisco, 1998)
• Farrugia, C.A., and Groves, M.J.: The Effect of Ethanol and Sodium Sulfate on the Molecular Behavior of Gelatin. Acta Pharmaceutica Turcica 40: S-53, 1998 (First International Postgraduate Research Symposium on Pharmaceutics, Istanbul, 1998)
• Farrugia, C.A., and Groves, M.J.: Gelatin Denaturation and Renaturation Processes in Solution. Pharm. Res. 14: S-160, 1997 (American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Boston, 1997)

Oral and Poster Presentations

• Lia, F., Farrugia, C., and Zammit Mangion, M.: Determination of olive oil antioxidant activity and phenolic profiling. (Ninth National Chemistry Symposium, Department of Chemistry, University of Malta, 2016)
• Attard, J., Ellul, M., and Farrugia, C.: Physicochemical Properties of Dispersions of Clozapine, 4 Acetamidophenol and Venlafaxine Hydrochloride in Hydrophobic Media. (Eighth National Chemistry Symposium, Department of Chemistry, University of Malta, 2015)
• Calleja, A., Farrugia, C., and Zammit Mangion, M.: Genetic Analysis Using DNA Molecular Markers of the ‘Malti’ Olive Variety Found on the Maltese Islands. (Eighth National Chemistry Symposium, Department of Chemistry, University of Malta, 2015)
• Mizzi, M., Duca, D., and Farrugia, C.: A Study on the Solubility Of Frangula Emodin. (Eighth National Chemistry Symposium, Department of Chemistry, University of Malta, 2015)
• Zammit Mamo, R., Ellul, M., and Farrugia, C.: A Study of Surfactant Effects on the Physical Chemistry of Vegetable and Mineral Oils. (Eighth National Chemistry Symposium, Department of Chemistry, University of Malta, 2015)
• Popova, M., Trusheva, B., Cutajar, S., Antonova, D., Mifsud, D., Farrugia, C., and Bankova, V.: Botanical Sources of the Biomarkers of Mediterranean Propolis. (Seventh National Chemistry Symposium, Department of Chemistry, University of Malta, 2012)
• Grixti, J.M., Farrugia, C.A., Hunter, G., and Hunter, T.: Expression, Purification and Characterisation of Human Copper-Zinc Superoxide Dismutase Protein and Human-Escherichia coli Copper-Zinc Superoxide Dismutase Chimeric Protein. (Seventh National Chemistry Symposium, Department of Chemistry, University of Malta, 2012)
• Magro, K., and Farrugia, C.: Physicochemical Properties of Ciprofloxacin Formulations. (Seventh National Chemistry Symposium, Department of Chemistry, University of Malta, 2012)
• Farrugia, M., Azzopardi, A., and Farrugia, C.: Method Development Studies on the HPLC Analysis of Candesartan Cilexetil using a Core-Shell Column. (Seventh National Chemistry Symposium, Department of Chemistry, University of Malta, 2012)
• Ellul, M., Sinagra, E., and Farrugia, C.: Physicochemical Parameters as a Predictive Tool for Optimum Dispersion of Active Pharmaceutical Ingredients. (Seventh National Chemistry Symposium, Department of Chemistry, University of Malta, 2012)
• Gatt, L., Hunter, G.J., Hunter, T., and Farrugia, C.A.: Purification, Characterisation and Crystallisation of Manganese Superoxide Dismutase from Mus musculus. (Seventh National Chemistry Symposium, Department of Chemistry, University of Malta, 2012)
• Azzopardi, Y., Frey, H.H., and Farrugia, C.: The Effect of Micro-Organisms on Ghost Peaks in a Reversed Phase HPLC System. (Sixth National Chemistry Symposium, Department of Chemistry, University of Malta, 2011)
• Cassar, C., Frey, H.H., and Farrugia, C.: Core-Shell Particle Column Performance in Acetylsalicylic Acid Related Substances Testing by Rapid Resolution Liquid Chromatography. (Sixth National Chemistry Symposium, Department of Chemistry, University of Malta, 2011)
• Darmanin, K., Frey, H.H., and Farrugia, C.: The Effect of Particle Size on the Intrinsic Dissolution of Acetylsalicylic Acid. (Sixth National Chemistry Symposium, Department of Chemistry, University of Malta, 2011)
• Bartolo, K., and Farrugia, C.: The Effect of Humidity on the Flow Properties of Microcrystalline Cellulose. (Sixth National Chemistry Symposium, Department of Chemistry, University of Malta, 2011)
• Aquilina, S., Farrugia, C., and Sinagra, E.: Molecular Weight Distributions of Dilute Bovine Gelatin and Cold Water Fish Skin Gelatin Solutions. (Sixth National Chemistry Symposium, Department of Chemistry, University of Malta, 2011)
• Bonetta, R., Hunter, T., Hunter, G.J., and Farrugia, C.A.: Purification and Crystallisation of Iron-Substituted Manganese Superoxide Dismutase-2 from Caenorhabditis elegans. (Sixth National Chemistry Symposium, Department of Chemistry, University of Malta, 2011)
• Scerri, L., Saliba, O., and Farrugia, C.: Influence of Adsorption During Grinding on the Analytical Quantification of Active Ingredients in Medicinal Products. (Fifth National Chemistry Symposium, Department of Chemistry, University of Malta, 2010)
• Micallef, M., Frey, H., and Farrugia, C.A.: A Preliminary Investigation of Ghost Peaks in a Reversed-Phase Gradient HPLC System. (Fourth National Chemistry Symposium, Department of Chemistry, University of Malta, 2008)
• Camilleri, R., Schembri, O., and Farrugia, C.A.: Stability Studies on Analytical Solutions in a Pharmaceutical Laboratory. (Fourth National Chemistry Symposium, Department of Chemistry, University of Malta, 2008)
• Schembri, M.G., Sinagra, E., and Farrugia, C.A.: Ethanolic Desolvation of Dilute Fish-Skin Gelatin Solutions. (Fourth National Chemistry Symposium, Department of Chemistry, University of Malta, 2008)
• Cortis, R., Farrugia, C.A., and Sinagra, E.: The Role of Electrostatic Interactions in the Desolvation of Isoionic Gelatin Solutions. (Third National Chemistry Symposium, Department of Chemistry, University of Malta, 2006)
• Farrugia, C.A.: Euromed Pharmaceutical Industry: Applying national experiences to regional development. (€uro-Mediterranean Investment Summit, Marseille, 2005)
• Mifsud, J., Farrugia, C.A., and Sinagra, E.: Gelatin Nanoparticle Production: An In-Process Study Using Size Exclusion Chromatography (Second National Chemistry Symposium, Department of Chemistry, University of Malta, 2004)
• Aquilina, A., Farrugia, C.A., and Sinagra, E.: Ethanolic Fractionation of Gelatin Solutions. (First National Chemistry Symposium, Department of Chemistry, University of Malta, 2002)
• Farrugia, C.A., and Groves, M.J.: The Formulation of Gelatin Nanoparticles and their Effect on Melanoma Growth In Vivo. (Fourth Maltese Medical School Conference, Faculty of Medicine and Surgery, University of Malta, 1999)
• Farrugia, C.A.: Gelatin Behavior in Dilute Aqueous Solution: Designing a Particulate Formulation. (Department of Pharmaceutics and Pharmacodynamics, College of Pharmacy, University of Illinois at Chicago, 1998)
• Farrugia, C.A., and Groves, M.J.: The Effect of BCG, BCG Filtrate, and an Immunostimulant Derived From BCG on the B16-F1 Melanoma Cell Line both In Vitro and In Vivo. (Second Annual Student and Resident Research Poster Forum, College of Pharmacy, University of Illinois at Chicago, 1996)
• Farrugia, C.A.: The Role of Fibronectin in Tumor Invasion and Metastasis. (Department of Pharmaceutics and Pharmacodynamics, College of Pharmacy, University of Illinois at Chicago, 1996)

Invited Lectures