| Sub-title | |
| Authors | C Savona Ventura MD, DScMed A Schranz MD, DSc Marcelle Chircop MD, MRCOG |
| Abstract | The aetiology of Type 2 diabetes [NIDDM] is assumed to involve a multiplicity of causal factors involving both genetic and environmental, including intrauterine, components. Aim: To identify the relationship of various aspects of family history and hence the possible role of genetic influence in the development of Type 2 DM in the Maltese population. Methods: The family history details of a study population undergoing an oGTT during pregnancy was assessed during pregnancy and at follow-up eight years postpartum. The findings were related to previous national epidemiological studies. Results: The study showed a definite statistical correlation between a maternal and sibling family history of diabetes with the onset of GDM/GIGT and later Type 2 DM. No such correlation was shown with a paternal or grandparent family history. Conclusions: The findings suggest that genetic factors are poor determinants for adult-onset GDM or Type 2 DM, the major role player being apparently alterations in the intrauterine environment of the fetus. |
Published in: | |
| Journal | Malta Medical Journal |
| Volume | 15 Issue 02 |
| Pages | 25 - 27 |
| Date | 01/11/2003 |
| Link to journal | |
| Key words | environment, family history, genetics, gestational diabetes, type 2 diabetes |