Remission during Pregnancy of Severe Chronic Hypertension due to 11-s Hydroxylase Deficiency

Sub-title
AuthorsGerhard Attard MD, MRCP (UK)
M J Cachia MD, MRCP (UK)
AbstractWhen hypertension is a result of an underlying identifiable abnormality, the latter's early discovery can lead to a timely cure of the hypertension and the prevention of its complications. We present a case of high blood pressure lowered by pregnancy, suggestive of an endocrine cause. This was confirmed following a detailed history which revealed severe hypertension intractable to therapy, yet which remitted during pregnancy. A diagnosis of 11-beta hydroxylase deficiency was made consequent upon the finding of raised serum 11-desoxycorticosterone levels. The blood pressure was finally controlled with glucocorticoid replacement therapy and spironolactone.

Published in:
JournalMalta Medical Journal
Volume16 Issue 02
Pages40 - 41
Date01/07/2004
Link to journal

Key words11-desoxycorticosterone, hypertension, pregnancy

Compiled by: Dr. I. Stabile    Dr. J. Pace