| Sub-title | |
| Authors | C Calamatta G Buhagiar |
| Abstract | Objectives: Overweight/obese non-diabetics and overweight/obese type 2 diabetic (T2DM) subjects were evaluated: (a) to investigate the prevalence of microalbuminuria in these subjects (b) to study the relation between albumin-to-creatinine ratio (ACR) and the following clinical parameters: waist-to-hip ratio (WHR), waist circumference (WC), body mass index (BMI) and blood pressure and (c) to investigate the effect of a 6-week weight loss program. Study: ACR was evaluated in 51 overweight/obese non-diabetics with BMI 31.3 0.64 (s.e.m.) kg/m2, 20 overweight/obese diabetics with BMI 30.9 0.68 kg/ m2 and in 30 control subjects with BMI 23.1 0.26 kg/m2. Urinary albumin and creatinine levels were determined from first morning spot urine samples, before and after a 6-week weight loss program as were BMI, WHR and WC. Blood pressure was measured at the beginning of the program. Results: At the beginning of a 6-week weight-loss program, logACR was significantly higher in the overweight/obese non-diabetic (p<0.001) and overweight/obese T2DMs (p=0.007) than in controls. LogACR was significantly reduced in the overweight/ obese non-diabetics (1.58 0.13 mg/g to 0.90 0.19 mg/g, p<0.001) and overweight/ obese T2DMs (1.27 0.20 mg/g to 0.60 0.24 mg/g, p=0.005) by the end of the program. An elevated logACR was evident in a non-diabetic subject with a BMI of 29.3 Kg/m2. LogACR was positively correlated to basal diastolic blood pressure (r=0.357, p=0.010) and BMI (r=0.345, p=0.013) in the overweight/obese non-diabetic population. Conclusion: A major reduction in the logACR of all subjects was observed with weight reduction. Prompt remission of microalbuminuria was observed in an overweight non-diabetic subject after weight loss. Weight loss may be an important therapeutic approach for future prevention of renal complications in overweight/obese individuals. |
Published in: | |
| Journal | Malta Medical Journal |
| Volume | Volume 15 (suppl) |
| Pages | - |
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| Key words | microalbuminuria, obesity, body mass index |