Cost value of side effect reduction

Sub-title
AuthorsM Zarb Adami
A Serracino Inglott
L M Azzopardi
AbstractThe aim of the study was to determine how much patients are prepared to pay for a medicine with reduced occurrence of adverse effects. A questionnaire consisting of 10 closed-type questions was developed. Price patients are prepared to pay more for a non-steroidal anti-inflammatory drug which is not associated with gastric irritation as opposed to a classical non-steroidal anti-inflammatory drug known to cause possible gastric side effects was estimated. Inter-rater reliability of the questionnaire was tested: 20 patients visiting a community pharmacy were interviewed by two raters. Face and content validity were evaluated through the setting up of an expert panel of judges. Subsequently, two investigators addressed the questionnaire to 660 (518 females, 142 males) clients who were approached as a convenience sample from 8 community pharmacies and 3 shopping centres. Statistical analysis was carried out using Biomedical Data Package software. Face and content validity of the questionnaire were strong. Reliability correlation coefficient and internal consistency were high (rs= 0.95, Cronbachs alpha = 0.98). Use of ibuprofen: 43% rarely, 26% once a month, 3% once a week, 2% >once a week and 1% daily. 12% of clients suffered from stomach pain as a result of ibuprofen. Amount of money in US$ for 48 tablets patients are prepared to pay more for a product with less side effects: 40% -none, 25% - $1.5, 16%- $3, 2%- $6, 7%- >$6, 10%- no answer. Reasons why patients are in general unwilling to pay more for products with none or less gastrointestinal side instead of a conventional non-steroidal anti-inflammatory drug vary according to patients perceived need for the medication.

Published in:
JournalMalta Medical Journal
VolumeVolume 15 (suppl)
Pages -
Date
Link to journal

Key wordscost value, side effect reduction, pharmacy

Compiled by: Dr. I. Stabile    Dr. J. Pace